ML162-yne

• CAT Number: I041132
• CAS Number: 2883115-46-4
• Molecular Formula: C25H22Cl2N2O3S
• Molecular Weight: 501.42
• Purity: ≥95%
• Synonyms: 2-(3-chloro-N-(2-chloroacetyl)-4-prop-2-ynoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
• InChI: InChI=1S/C25H22Cl2N2O3S/c1-2-14-32-21-11-10-19(16-20(21)27)29(23(30)17-26)24(22-9-6-15-33-22)25(31)28-13-12-18-7-4-3-5-8-18/h1,3-11,15-16,24H,12-14,17H2,(H,28,31)
• InChIKey: AFUOBFISLHQJJJ-UHFFFAOYSA-N
• SMILES: C#CCOC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

ML162-yne（Cat No.:I041132）is a small molecule inhibitor that targets ATP-citrate lyase (ACL), an enzyme critical for the synthesis of acetyl-CoA, a central metabolite involved in lipid biosynthesis and cellular metabolism. By inhibiting ACL, ML162-yne disrupts key metabolic pathways, particularly in cancer cells that rely on altered metabolic processes for growth and survival. This inhibition impedes the production of fatty acids and cholesterol, essential for cell membrane synthesis. ML162-yne holds potential as a therapeutic agent in cancer and other metabolic diseases, where altering cellular metabolism could limit disease progression.