For research use only. Not for therapeutic Use.
ML167（Cat No.:I008086）is a selective inhibitor of the enzyme protein kinase D (PKD), which plays a critical role in various cellular processes, including cell proliferation, survival, and migration. By inhibiting PKD, ML167 disrupts signaling pathways involved in cancer progression and inflammation, making it a valuable tool in cancer research. Preclinical studies have demonstrated its potential to inhibit tumor growth and metastasis in various cancer models. Additionally, ML167 is being explored for its effects on cardiac function and neurodegenerative diseases, highlighting its versatility as a compound in both cancer and broader therapeutic research.
| Catalog Number | I008086 |
| CAS Number | 1285702-20-6 |
| Molecular Formula | C19H17N3O3 |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IC50 | 136 nM |
| IUPAC Name | [5-[4-[(5-methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol |
| InChI | InChI=1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22) |
| InChIKey | ROCFOIBAEVAOLQ-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO |
| Reference | </br>1: Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2010 Mar 29 [updated 2011 Mar 3]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK56236/ PubMed PMID: 21735605. |
