ML170

For research use only. Not for therapeutic Use.

  • CAT Number: I012425
  • CAS Number: 899717-26-1
  • Molecular Formula: C17H18N2O3S
  • Molecular Weight: 330.40
  • Purity: ≥95%
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ML170(CAT: I012425) is a highly specific allosteric activator of the M2 isoform of human pyruvate kinase (PKM2), a critical enzyme in glycolysis that plays a pivotal role in cancer metabolism. By selectively activating PKM2, ML170 shifts its conformation to enhance enzymatic activity, promoting pyruvate production and reducing the diversion of glycolytic intermediates into anabolic pathways. This compound is particularly valuable in oncology research, aiding studies on tumor metabolism, energy production, and the Warburg effect. ML170 is a powerful tool for exploring PKM2 as a therapeutic target and advancing research into cancer cell metabolism and proliferation.


Catalog Number I012425
CAS Number 899717-26-1
Synonyms

N-(3,4-Dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide; ML-170

Molecular Formula C17H18N2O3S
Purity ≥95%
IUPAC Name N-(3,4-dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide
InChI InChI=1S/C17H18N2O3S/c1-11-3-5-14(9-12(11)2)19-23(21,22)15-6-7-16-13(10-15)4-8-17(20)18-16/h3,5-7,9-10,19H,4,8H2,1-2H3,(H,18,20)
InChIKey SNFROMRRGGKYTF-UHFFFAOYSA-N
SMILES CC1=C(C=C(C=C1)NS(=O)(=O)C2=CC3=C(C=C2)NC(=O)CC3)C

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