For research use only. Not for therapeutic Use.
ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1].
ML192 inhibits the β-arrestin trafficking induced by 10 μM L-α lysophosphatidylinositol (LPI) or 1 μM ML186 with IC50 values of 0.70 µM and 0.29 µM, respectively[1].
ML192 significantly inhibits ERK1/2 phosphorylation in GPRSS-expressing U2OS cells with an IC50 value of 1.1 µM[1].
ML192 (0, 10, 30 and 100 µM) reduces the translocation of PKCβII in cells with the Wild-Type GPR55 receptor[1].
| Catalog Number | I007866 |
| CAS Number | 460331-61-7 |
| Synonyms | furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone |
| Molecular Formula | C20H22N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H22N4O2S/c1-13-21-18(17-14-5-2-3-7-16(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)15-6-4-12-26-15/h4,6,12H,2-3,5,7-11H2,1H3 |
| InChIKey | GDPDARVUXXOYAJ-UHFFFAOYSA-N |
| SMILES | CC1=NC(=C2C3=C(CCCC3)SC2=N1)N4CCN(CC4)C(=O)C5=CC=CO5 |
| Reference | [1]. Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69. |
