For research use only. Not for therapeutic Use.
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect[1].
| Catalog Number | I011041 |
| CAS Number | 1221186-52-2 |
| Synonyms | 10-[(3-methoxyphenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,11-tetraen-9-one |
| Molecular Formula | C18H17N3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H17N3O3S2/c1-20-14-8-15(26(3)23)25-17(14)13-9-19-21(18(22)16(13)20)10-11-5-4-6-12(7-11)24-2/h4-9H,10H2,1-3H3 |
| InChIKey | MORBXZMIXGYQDB-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)OC)SC(=C2)S(=O)C |
| Reference | [1]. Matthew B Boxer, et al. Identification of activators for the M2 isoform of human pyruvate kinase Version 3. 2009 Sep 1 [updated 2011 Mar 3]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. |
