For research use only. Not for therapeutic Use.
ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM)[1].
ML233 shows potentially significant binding against several other receptors, including the 5-HT1A, α2C adrenergic, and benzylpiperazine receptors and norepinephrine transporter. ML233 shows some toxicity (LC50=25.8 μM) toward human hepatocyctes[1].
| Catalog Number | I045833 |
| CAS Number | 2080311-92-6 |
| Synonyms | [(Z)-(5-cyclohexyl-2-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] benzenesulfonate |
| Molecular Formula | C19H21NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H21NO4S/c1-14-12-19(21)17(15-8-4-2-5-9-15)13-18(14)20-24-25(22,23)16-10-6-3-7-11-16/h3,6-7,10-13,15H,2,4-5,8-9H2,1H3/b20-18- |
| InChIKey | RSMZOLWJZGIWOV-ZZEZOPTASA-N |
| SMILES | CC1=CC(=O)C(=CC1=NOS(=O)(=O)C2=CC=CC=C2)C3CCCCC3 |
| Reference | [1]. Khan P, et al. National Center for Biotechnology Information; 2011. Functional agonists of the apelin (APJ) receptor. In Probe Reports from the NIH Molecular Libraries Program. [2]. Pasha Khan, et al. National Center for Biotechnology Information; 2011. Functional agonists of the apelin (APJ) receptor. In Probe Reports from the NIH Molecular Libraries Program. |
