ML252

• CAT Number: I047618
• CAS Number: 2309887-61-2
• Molecular Formula: C20H24N2O.HCl
• Molecular Weight: 344.88
• Purity: ≥95%
• IUPAC Name: (2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide;hydrochloride
• InChI: InChI=1S/C20H24N2O.ClH/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22;/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23);1H/t17-;/m0./s1
• SMILES: CC[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=CC=C2N3CCCC3.Cl

Potent, selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM, and >40-fold selective over KCNQ1). A useful in vivo tool molecule to study KCNQ2 pharmocology.
KEYWORDS: ML 252 | supplier | KCNQ2 inhibitor | ML-252 | CAS [2309887-61-2] – [1392494-64-2] – [1392494-65-3] | Potassium | voltage-gated | Kv7.2 | Alzheimer’s | brain penetrant | selective | KCNQ1 | CNS

Reference

YY Cheung et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (ML252)… J Med Chem. 2012 Aug 9;55(15):6975-9.