ML277

• CAT Number: I001530
• CAS Number: 1401242-74-7
• Molecular Formula: C23H25N3O4S2
• Molecular Weight: 471.6
• Purity: ≥95%
• Synonyms: (R,Z)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carbimidic acid
• Target: Potassium Channel
• Solubility: DMSO: ≥ 56 mg/mL
• Storage: Store at -20C
• IC50: 270 nM (EC50) [1]
• InChIKey: OXQNLLVUVDAEHC-OAQYLSRUSA-N

ML277(CAT: I001530) is a novel, potent, and selective activator of the K(v)7.1 (KCNQ1) potassium channel. The K(v)7.1 channel plays a critical role in the regulation of cardiac repolarization and is involved in maintaining normal heart rhythm. Activation of the K(v)7.1 channel by ML277 enhances its activity, leading to the modulation of cardiac repolarization. ML277’s selectivity for the K(v)7.1 channel makes it a valuable tool compound for studying channel function and exploring its potential therapeutic applications in conditions related to abnormal cardiac repolarization.

Reference

[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.