For research use only. Not for therapeutic Use.
ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
| Catalog Number | I011463 |
| CAS Number | 1523437-16-2 |
| Synonyms | N-[4-(4-chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide |
| Molecular Formula | C16H16ClN3O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H16ClN3O6S/c17-11-7-9-19(10-8-11)27(24,25)13-3-1-12(2-4-13)18-16(21)14-5-6-15(26-14)20(22)23/h1-6,11H,7-10H2,(H,18,21) |
| InChIKey | XKMLYHZJKCRLOI-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1Cl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC=C(O3)[N+](=O)[O-] |
| Reference | [1]. Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128(22):3523. |
