ML303

• CAT Number: I019154
• CAS Number: 1638211-04-7
• Molecular Formula: C₂₁H₁₆F₃N₃O₂
• Molecular Weight: 399.37
• Purity: ≥95%
• Target: Influenza Virus
• Storage: 2-8°C
• IUPAC Name: 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]pyridin-4-yl]phenol
• InChI: InChI=1S/C21H16F3N3O2/c1-12-19-16(13-3-8-17(28)18(11-13)29-2)9-10-25-20(19)27(26-12)15-6-4-14(5-7-15)21(22,23)24/h3-11,28H,1-2H3
• InChIKey: YBRHGNCGFMRGSV-UHFFFAOYSA-N
• SMILES: CC1=NN(C2=NC=CC(=C12)C3=CC(=C(C=C3)O)OC)C4=CC=C(C=C4)C(F)(F)F

ML303（Cat No.:I019154）is a potent and selective inhibitor of the kinase activity of cyclin-dependent kinase 2 (CDK2). It plays a key role in regulating the cell cycle and is particularly valuable in cancer research, where dysregulated CDK2 activity contributes to uncontrolled cell proliferation. By inhibiting CDK2, ML303 shows promise in modulating cell cycle progression, particularly in the G1/S phase transition, making it a valuable tool for studying cell division, cancer progression, and potential therapeutic interventions targeting CDK2 for cancer treatment.

Reference

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.