ML346

• CAT Number: I000100
• CAS Number: 100872-83-1
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.26
• Purity: ≥95%
• Target: Hsp70
• Solubility: DMSO：≥ 21 mg/mL
• Storage: 3 years -20C powder
• IC50: 4600 nM (EC50)
• InChI: InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H,1H3,(H2,15,16,17,18,19)/b3-2+
• InChIKey: IXYLVJHFJKDHRM-NSCUHMNNSA-N
• SMILES: O=C(NC(NC/1=O)=O)C1=CC=CC2=CC=C(OC)C=C2

ML346 (CAT: I000100) is a novel activator of heat shock protein 70 (Hsp70). Hsp70 is a chaperone protein involved in cellular stress response and protein folding. ML346 has been shown to specifically induce the expression and activation of Hsp70, leading to enhanced cellular protection against various stressors, including oxidative stress and protein misfolding. This activation of Hsp70 can have potential therapeutic applications in diseases associated with protein misfolding, such as neurodegenerative disorders.

Reference

[1]. Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 17.