ML354

• CAT Number: R034530
• CAS Number: 89159-60-4
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.29
• Purity: ≥95%
• IUPAC Name: (1-methyl-5-nitro-3-phenylindol-2-yl)methanol
• InChI: InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3
• SMILES: CN1C2=C(C=C(C=C2)[N+](=O)[O-])C(=C1CO)C3=CC=CC=C3

ML354 is a potent and selective protease activated receptor 4 (PAR4) antagonist with an IC50 value of 140 nM.
KEYWORDS: ML354 | Supplier | PAR4 antagonist | VU0099704 | ML 354 | ML-354 | VU 0099704 | VU-0099704 | CAS [89159-60-4] | Thrombin | Thrombin (PAR) | Antagonist | Receptors | Thrombotic disorder

Reference

W Wen et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713.