For research use only. Not for therapeutic Use.
ML402(CAT: I013180) is a selective activator of the TREK-1 potassium channel. TREK-1 (TWIK-related K+ channel 1) is a member of the two-pore domain potassium channel family and is involved in regulating neuronal excitability and neuroprotection. ML402 binds to and activates TREK-1 channels, leading to an increase in potassium efflux and membrane hyperpolarization. This activation of TREK-1 may have potential therapeutic applications in conditions such as pain, epilepsy, and mood disorders.
| Catalog Number | I013180 |
| CAS Number | 298684-44-3 |
| Molecular Formula | C₁₄H₁₄ClNO₂S |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | DMSO: 150 mg/mL |
| IUPAC Name | N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide |
| InChI | InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17) |
| InChIKey | RULQUKFOBAPKKR-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)Cl)OCCNC(=O)C2=CC=CS2 |
| Reference | [1]. Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368. |
