For research use only. Not for therapeutic Use.
ML417（Cat No.:I015207）is a selective small-molecule agonist of G protein–coupled receptor 68 (GPR68, also known as OGR1), a proton-sensing receptor implicated in pH regulation, inflammation, and cancer biology. By activating GPR68, ML417 modulates intracellular calcium signaling and downstream pathways, making it a valuable probe for investigating the role of extracellular acidity in cellular physiology. Research highlights its applications in studying tumor microenvironment responses, inflammatory signaling, and cardiovascular regulation. ML417 is widely used in pharmacological and biomedical studies exploring GPR68-mediated mechanisms.
| CAS Number | 1386162-69-1 |
| Synonyms | 1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone |
| Molecular Formula | C22H25N3O3 |
| Purity | ≥95% |
| IUPAC Name | 1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone |
| InChI | InChI=1S/C22H25N3O3/c1-27-18-6-8-19(9-7-18)28-15-14-24-10-12-25(13-11-24)22(26)21-16-17-4-2-3-5-20(17)23-21/h2-9,16,23H,10-15H2,1H3 |
| InChIKey | HAZPAMUWUHDPDA-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)OCCN2CCN(CC2)C(=O)C3=CC4=CC=CC=C4N3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
