MLN-4760

• CAT Number: I008114
• CAS Number: 305335-31-3
• Molecular Formula: C19H23Cl2N3O4
• Molecular Weight: 428.31
• Purity: ≥95%
• Synonyms: MLN-4760; MLN 4760; MLN4760.;(2S)-2-[[(2S)-3-[3-[(3,5-dichlorophenyl)methyl]imidazol-4-yl]-1-hydroxy-1-oxopropan-2-yl]amino]-4-methylpentanoic acid
• Target: ACE2 inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2S)-2-[[(1S)-1-carboxy-2-[3-[(3,5-dichlorophenyl)methyl]imidazol-4-yl]ethyl]amino]-4-methylpentanoic acid
• InChI: InChI=1S/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/m0/s1
• InChIKey: NTCCRGGIJNDEAB-IRXDYDNUSA-N
• SMILES: CC(C)CC(C(=O)O)NC(CC1=CN=CN1CC2=CC(=CC(=C2)Cl)Cl)C(=O)O

MLN-4760 is a potent and selective inhibitor of angiotensin-converting enzyme 2 (ACE2), an enzyme involved in the renin-angiotensin system (RAS) that plays a critical role in regulating blood pressure and fluid balance. By inhibiting ACE2, MLN-4760 is used in research to explore the effects of ACE2 modulation on cardiovascular and renal function, as well as its potential therapeutic implications. ACE2 is also involved in the entry of certain viruses, such as SARS-CoV-2, into host cells, making MLN-4760 a valuable tool for studying viral pathogenesis and the broader role of ACE2 in disease mechanisms.