MLN120B

• CAT Number: I004879
• CAS Number: 783348-36-7
• Molecular Formula: C19H15ClN4O2
• Molecular Weight: 366.80
• Purity: ≥95%
• Synonyms: N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide
• Target: IKK
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IC50: MLN120B (20 umol/L) induced up to 35% and 75% inhibition, assessed by MTT assay and [3H]thymidine uptakein multiple myeloma cell lines, respectively.
• InChI: InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25)
• InChIKey: ZNOLRTPMNMPLHY-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4

MLN120B（Cat No.:I004879）is a small-molecule inhibitor of the protein kinase aurora A, a crucial regulator of mitosis, the process of cell division. Aurora A kinase plays a key role in spindle formation, chromosome alignment, and segregation during cell division. Overexpression or aberrant activation of aurora A is often associated with various cancers, leading to uncontrolled cell proliferation. MLN120B inhibits aurora A activity, preventing proper cell division, thereby causing mitotic defects and inducing cancer cell death. It has shown potential as an anticancer agent, particularly in treating solid tumors and hematological malignancies, with ongoing clinical investigations.