For research use only. Not for therapeutic Use.
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs)[1].
MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605[1].
| Catalog Number | I045500 |
| CAS Number | 862975-18-6 |
| Synonyms | N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine |
| Molecular Formula | C16H11FN4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H11FN4O2S/c1-22-10-7-5-9(6-8-10)14-20-21-15(23-14)19-16-18-13-11(17)3-2-4-12(13)24-16/h2-8H,1H3,(H,18,19,21) |
| InChIKey | MJTZAHHYEVPIDG-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2=NN=C(O2)NC3=NC4=C(C=CC=C4S3)F |
| Reference | [1]. Lucia Musumeci, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015 Feb 17;131(7):656-68. |
