For research use only. Not for therapeutic Use.
MLS0315771(CAT: I019667) is a potent and biologically active competitive inhibitor of phosphomannose isomerase (MPI), a key enzyme in the mannose metabolism pathway. By targeting MPI, it disrupts the conversion of mannose-6-phosphate to fructose-6-phosphate, making it valuable for studying metabolic processes and congenital disorders of glycosylation (CDG). This compound is particularly relevant in the field of metabolic diseases, supporting research into therapeutic strategies for glycosylation-related disorders. With its high specificity and efficacy, MLS0315771 is a critical tool for exploring mannose metabolism and developing innovative treatments for metabolic dysfunctions.
| Catalog Number | I019667 |
| CAS Number | 727664-91-7 |
| Molecular Formula | C₁₅H₁₂FNOS |
| Purity | ≥95% |
| IUPAC Name | 2-(2,5-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3-one |
| InChI | InChI=1S/C15H12FNOS/c1-9-3-4-10(2)13(7-9)17-15(18)12-6-5-11(16)8-14(12)19-17/h3-8H,1-2H3 |
| InChIKey | GRGDWLDSVPJEJU-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C)N2C(=O)C3=C(S2)C=C(C=C3)F |
| Reference | [1]. Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8. |
