For research use only. Not for therapeutic Use.
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling[1].
MLS1082 potentiate β-Arrestin- and G protein-Mediated D1R signaling[1].
| Catalog Number | I032443 |
| CAS Number | 883958-36-9 |
| Synonyms | 2-cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione |
| Molecular Formula | C24H23N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H23N3O2/c1-26-19-15-9-8-14-18(19)21(28)20-23(26)25-22(16-10-4-2-5-11-16)27(24(20)29)17-12-6-3-7-13-17/h3,6-9,12-16H,2,4-5,10-11H2,1H3 |
| InChIKey | HZGMAMIIHBRAAR-UHFFFAOYSA-N |
| SMILES | CN1C2=CC=CC=C2C(=O)C3=C1N=C(N(C3=O)C4=CC=CC=C4)C5CCCCC5 |
| Reference | [1]. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696. [2]. Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. |
