For research use only. Not for therapeutic Use.
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1].
MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM[1].
| Catalog Number | I019435 |
| CAS Number | 2097853-86-4 |
| Synonyms | 1-[2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl]urea |
| Molecular Formula | C20H21Cl2N7O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21Cl2N7O3/c1-11(32-2)18-14(10-23-16-8-15(22)27-29(16)18)26-20(31)25-12-7-13(21)17(24-9-12)19(30)28-5-3-4-6-28/h7-11H,3-6H2,1-2H3,(H2,25,26,31)/t11-/m0/s1 |
| InChIKey | OJTGJRAKRGEDPI-NSHDSACASA-N |
| SMILES | CC(C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=C(N=C3)C(=O)N4CCCC4)Cl)OC |
| Reference | [1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. |
