For research use only. Not for therapeutic Use.
MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC50 value of 3 nM.
| Catalog Number | I045208 |
| CAS Number | 1832576-25-6 |
| Synonyms | 1-[2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]urea |
| Molecular Formula | C17H15Cl2N9O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15Cl2N9O2/c1-9(30-2)15-12(8-20-14-6-13(19)26-27(14)15)25-17(29)24-10-5-11(18)16(21-7-10)28-22-3-4-23-28/h3-9H,1-2H3,(H2,24,25,29)/t9-/m0/s1 |
| InChIKey | GBIASRXDYFFUED-VIFPVBQESA-N |
| SMILES | CC(C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=C(N=C3)N4N=CC=N4)Cl)OC |
| Reference | [1]. Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608. |
