MM-102 trifluoroacetate

• CAT Number: I005794
• CAS Number: 1883545-52-5
• Molecular Formula: C37H50F5N7O6
• Molecular Weight: 783.83
• Purity: ≥95%
• Target: MLL
• Solubility: 10 mM in DMSO, 10 mM in H2O
• Storage: Store at -20°C
• IC50: 2.4 nM
• IUPAC Name: N-[bis(4-fluorophenyl)methyl]-1-[[(2S)-5-(diaminomethylideneamino)-2-[[2-ethyl-2-(2-methylpropanoylamino)butanoyl]amino]pentanoyl]amino]cyclopentane-1-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C35H49F2N7O4.C2HF3O2/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24;3-2(4,5)1(6)7/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40);(H,6,7)/t27-;/m0./s1
• InChIKey: ZRKTWBXVGMHWHM-YCBFMBTMSA-N
• SMILES: CCC(CC)(C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC1(CCCC1)C(=O)NC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)NC(=O)C(C)C.C(=O)(C(F)(F)F)O

MM-102 trifluoroacetate(CAT: I005794) is a potent and selective inhibitor of the MLL1 (Mixed Lineage Leukemia 1) protein, a key epigenetic regulator involved in histone H3 lysine 4 (H3K4) methylation. This compound disrupts the interaction between MLL1 and its cofactor menin, thereby inhibiting MLL1-mediated transcriptional activity. MM-102 trifluoroacetate is widely used in cancer research, particularly for studying MLL1-rearranged leukemias and their dependency on the MLL1-menin interaction. Its high specificity and efficacy make it an invaluable tool for exploring epigenetic mechanisms, advancing therapeutic discovery, and developing targeted treatments for MLL1-driven malignancies.