MM-206

For research use only. Not for therapeutic Use.

  • CAT Number: R067084
  • CAS Number: 1809581-87-0
  • Molecular Formula: C22H12F5NO3S2
  • Molecular Weight: 497.46
  • Purity: ≥95%
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MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].


Catalog Number R067084
CAS Number 1809581-87-0
Synonyms

2,3,4,5,6-pentafluoro-N-(4-hydroxy-3-phenylsulfanylnaphthalen-1-yl)benzenesulfonamide

Molecular Formula C22H12F5NO3S2
Purity ≥95%
InChI InChI=1S/C22H12F5NO3S2/c23-16-17(24)19(26)22(20(27)18(16)25)33(30,31)28-14-10-15(32-11-6-2-1-3-7-11)21(29)13-9-5-4-8-12(13)14/h1-10,28-29H
InChIKey ZXJHEANDHXHGMV-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)SC2=C(C3=CC=CC=C3C(=C2)NS(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F)O
Reference

[1]. A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment. Blood.2015 Dec 3.126 (23): 569.

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