MM 54

• CAT Number: P000327
• CAS Number: 1313027-43-8
• Molecular Formula: C70H121N29O15S4
• Molecular Weight: 1737.16
• Purity: ≥95%

MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].
MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 µM[2].
MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity[2].

Reference

[1]. N J Maximilian Macaluso, et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem. 2011 Jun 6;6(6):1017-23.
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[2]. Elizabeth Harford-Wright, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140(11):2939-2954.
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