For research use only. Not for therapeutic Use.
MM3122（Cat No.:I042897）is a highly selective inhibitor of the transmembrane serine protease TMPRSS2, exhibiting an IC₅₀ value of 0.34 nM. By targeting TMPRSS2, MM3122 effectively blocks the entry of coronaviruses such as SARS-CoV-2 and MERS-CoV into human cells. In vitro studies demonstrate that MM3122 inhibits wild-type SARS-CoV-2 replication in human lung epithelial Calu-3 cells, with an IC₅₀ of approximately 0.01–0.02 µM. In vivo experiments using mouse models indicate that both prophylactic and therapeutic administration of MM3122 significantly reduces COVID-19 disease severity, as evidenced by decreased weight loss, reduced lung congestion, and diminished inflammatory cytokine production. These findings highlight MM3122’s potential as a promising candidate for the treatment and prevention of COVID-19 and other TMPRSS2-dependent viral infections.
| CAS Number | 2574390-27-3 |
| Synonyms | (2S)-2-[(2-acetamidoacetyl)amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide |
| Molecular Formula | C31H39N9O6S |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[(2-acetamidoacetyl)amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide |
| InChI | InChI=1S/C31H39N9O6S/c1-18(41)36-17-26(43)37-22(13-14-25(32)42)28(45)39-23(16-19-8-3-2-4-9-19)29(46)38-21(11-7-15-35-31(33)34)27(44)30-40-20-10-5-6-12-24(20)47-30/h2-6,8-10,12,21-23H,7,11,13-17H2,1H3,(H2,32,42)(H,36,41)(H,37,43)(H,38,46)(H,39,45)(H4,33,34,35)/t21-,22-,23-/m0/s1 |
| InChIKey | ZEPMYXYJCBQSLH-VABKMULXSA-N |
| SMILES | CC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC3=CC=CC=C3S2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
