MMAD-d8

• CAT Number: S000375
• Molecular Formula: C41H58D8N6O6S
• Molecular Weight: 779.11
• Purity: ≥95%
• IUPAC Name: (2S)-2,3,4,4,4-pentadeuterio-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]-3-(trideuteriomethyl)butanamide
• InChI: InChI=1S/C41H66N6O6S/c1-12-27(6)36(46(9)41(51)35(26(4)5)45-39(50)34(42-8)25(2)3)32(52-10)24-33(48)47-21-16-19-31(47)37(53-11)28(7)38(49)44-30(40-43-20-22-54-40)23-29-17-14-13-15-18-29/h13-15,17-18,20,22,25-28,30-32,34-37,42H,12,16,19,21,23-24H2,1-11H3,(H,44,49)(H,45,50)/t27-,28+,30-,31-,32+,34-,35-,36-,37+/m0/s1/i4D3,5D3,26D,35D
• InChIKey: BLUGYPPOFIHFJS-JVNODLFUSA-N
• SMILES: CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC

MMAD-d8（Cat No.:S000375） is a deuterated version of Monomethyl Auristatin D (MMAD), a potent synthetic antineoplastic agent used in antibody-drug conjugates (ADCs) targeting cancer cells. In MMAD-d8, eight hydrogen atoms are replaced with deuterium, enhancing the analytical tracing of the drug’s metabolism and distribution within the body. This modification is critical for studying the stability and efficacy of MMAD in clinical settings, particularly in its role as the cytotoxic component in ADCs that specifically target and kill tumor cells while minimizing the impact on normal cells, thus improving therapeutic outcomes.