For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.<br>IC50 value:<br>Target: Tubulin; ADCs toxin<br>For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).<br></p>
| Catalog Number | I002259 |
| CAS Number | 173441-26-4 |
| Molecular Formula | C41H67ClN6O6S |
| Purity | ≥95% |
| Target | Tubulin; ADCs toxin |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| Reference | <p style=/line-height:25px/> |
