For research use only. Not for therapeutic Use.
MMAF-OMe (Monomethyl auristatin F – O-methyl ester)(CAT: I005184) is a synthetic derivative of monomethyl auristatin F (MMAF), a potent antimitotic agent. It works by inhibiting tubulin polymerization, leading to cell cycle arrest and apoptosis in rapidly dividing cells. MMAF-OMe is commonly used in the development of antibody-drug conjugates (ADCs), where it serves as the cytotoxic payload linked to monoclonal antibodies that specifically target cancer cells. The O-methyl ester modification improves the stability of the compound, making it more suitable for targeted drug delivery. MMAF-OMe is a crucial tool in cancer therapy research, offering highly selective cytotoxicity while sparing normal cells.
| Catalog Number | I005184 |
| CAS Number | 863971-12-4 |
| Molecular Formula | C40H67N5O8 |
| Purity | ≥95% |
| Target | tubulin |
| Solubility | DMSO |
| Storage | -20°C |
