MMP-1-IN-1

For research use only. Not for therapeutic Use.

  • CAT Number: I042362
  • Molecular Formula: C14H17ClN2O3
  • Molecular Weight: 296.75
  • Purity: ≥95%
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MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC50 of 0.034 μM[1].
The high inhibitory activity of MMP-1-IN-1 (Compound 6) against MMP-1 might be due to a halogen bond interaction between the Cl substituent of MMP-1-IN-1 and residue ARG214 of MMP-1[1].


Catalog Number I042362
Synonyms

(2R)-2-[(3S)-3-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-1-yl]-N-hydroxypropanamide

Molecular Formula C14H17ClN2O3
Purity ≥95%
InChI InChI=1S/C14H17ClN2O3/c1-9(12(18)16-20)17-8-7-14(2,13(17)19)10-3-5-11(15)6-4-10/h3-6,9,20H,7-8H2,1-2H3,(H,16,18)/t9-,14+/m1/s1
InChIKey XZANSWYKOFTZSF-OTYXRUKQSA-N
SMILES CC(C(=O)NO)N1CCC(C1=O)(C)C2=CC=C(C=C2)Cl
Reference

[1]. Umedera K, et al. Design of MMP-1 inhibitors via SAR transfer and experimental validation. Sci Rep. 2022 Dec 3;12(1):20915.
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