For research use only. Not for therapeutic Use.
MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC50 of 0.034 μM[1].
The high inhibitory activity of MMP-1-IN-1 (Compound 6) against MMP-1 might be due to a halogen bond interaction between the Cl substituent of MMP-1-IN-1 and residue ARG214 of MMP-1[1].
Catalog Number | I042362 |
Synonyms | (2R)-2-[(3S)-3-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-1-yl]-N-hydroxypropanamide |
Molecular Formula | C14H17ClN2O3 |
Purity | ≥95% |
InChI | InChI=1S/C14H17ClN2O3/c1-9(12(18)16-20)17-8-7-14(2,13(17)19)10-3-5-11(15)6-4-10/h3-6,9,20H,7-8H2,1-2H3,(H,16,18)/t9-,14+/m1/s1 |
InChIKey | XZANSWYKOFTZSF-OTYXRUKQSA-N |
SMILES | CC(C(=O)NO)N1CCC(C1=O)(C)C2=CC=C(C=C2)Cl |
Reference | [1]. Umedera K, et al. Design of MMP-1 inhibitors via SAR transfer and experimental validation. Sci Rep. 2022 Dec 3;12(1):20915. |