MMP-13 inhibitor

• CAT Number: I003085
• CAS Number: 307002-71-7
• Molecular Formula: C17H23ClN2O3
• Molecular Weight: 338.83
• Purity: ≥95%
• Synonyms: N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide;hydrochloride
• Target: MMP
• Solubility: DMSO ≥ 35 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H
• InChIKey: PIOACXKZWXHBRB-UHFFFAOYSA-N
• SMILES: C1COCCN1CCCCNC(=O)C2=CC3=CC=CC=C3O2.Cl

CL-82198（Cat No.:I003085） is a selective MMP-13 inhibitor. CL-82198 binds to the entire S1′ pocket of MMP-13, which is the basis for its selectivity for MMP-13 and lack of inhibitory activity against other MMPs. CL-82198 can be used in the research of osteoarthritis (OA).

Reference

[1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488.

[2]. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53.