MMP-9/MMP-13 Inhibitor I

• CAT Number: R066951
• CAS Number: 204140-01-2
• Molecular Formula: C25H25N3O6S
• Molecular Weight: 495.55
• Purity: ≥95%
• Synonyms: N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-phenylbenzoyl)piperazine-2-carboxamide
• InChI: InChI=1S/C25H25N3O6S/c1-34-21-11-13-22(14-12-21)35(32,33)28-16-15-27(17-23(28)24(29)26-31)25(30)20-9-7-19(8-10-20)18-5-3-2-4-6-18/h2-14,23,31H,15-17H2,1H3,(H,26,29)
• InChIKey: KXZZWRQJKQVMKR-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2C(=O)NO)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4

MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs[1].
MMP-9/MMP-13 Inhibitor I (compound 35) inhibits MMP-1, MMP-3, and MMP-7 with IC50 values of 43 nM, 23 nM, and 931 nM, respectively[1].

Reference

[1]. M Cheng, et al. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J Med Chem. 2000 Feb 10;43(3):369-80.
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