For research use only. Not for therapeutic Use.
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively[1].
| Catalog Number | I043508 |
| CAS Number | 897799-81-4 |
| Synonyms | N-[3-(6-methyl-1H-benzimidazol-2-yl)phenyl]-3-phenylpropanamide |
| Molecular Formula | C23H21N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C23H21N3O/c1-16-10-12-20-21(14-16)26-23(25-20)18-8-5-9-19(15-18)24-22(27)13-11-17-6-3-2-4-7-17/h2-10,12,14-15H,11,13H2,1H3,(H,24,27)(H,25,26) |
| InChIKey | BCWAEMAJIICXQI-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)N=C(N2)C3=CC(=CC=C3)NC(=O)CCC4=CC=CC=C4 |
| Reference | [1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257. |
