For research use only. Not for therapeutic Use.
MMV008138 (Cat.No:I018733) is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM. MMV008138 targets the enzyme IspD in the MEP pathway of P. falciparum.
| Catalog Number | I018733 |
| CAS Number | 1679333-73-3 |
| Molecular Formula | C₁₈H₁₄Cl₂N₂O₂ |
| Purity | ≥95% |
| Reference | [1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559.<br>[2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9. |
