For research use only. Not for therapeutic Use.
MMV390048（Cat No.:I008120）is an investigational antimalarial compound that inhibits Plasmodium phosphatidylinositol 4-kinase (PI4K), disrupting the parasite’s life cycle. It has demonstrated efficacy against multiple stages of Plasmodium species, including liver and blood stages, and shows potential in preventing transmission. Clinical trials have indicated that MMV390048 is well-tolerated and possesses favorable pharmacokinetic properties, supporting its development as a single-dose treatment for malaria. Its unique mechanism of action and broad activity profile make it a promising candidate in the fight against malaria.
| Catalog Number | I008120 |
| CAS Number | 1314883-11-8 |
| Synonyms | MMV390048; MMV-390048; MMV 390048; MMV-048; MMV 048; MMV048.;5-(4-(methylsulfonyl)phenyl)-6/’-(trifluoromethyl)-[3,3/’-bipyridin]-2-amine |
| Molecular Formula | C18H14F3N3O2S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Desiccate at RT |
| IUPAC Name | 5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine |
| InChI | InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24) |
| InChIKey | RTJQABCNNLMCJF-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F |
| Reference | </br>1:Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735. PMID: 28446690 </br>2:Carbon-14 radiolabeling and tissue distribution evaluation of MMV390048. Sonopo MS, Pillay A, Chibale K, Marjanovic-Painter B, Donini C, Zeevaart JR.J Labelled Comp Radiopharm. 2016 Dec;59(14):680-688. doi: 10.1002/jlcr.3445. Epub 2016 Sep 20. PMID: 27646069 |
