For research use only. Not for therapeutic Use.
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Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
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In vitro: In the HEK293 cells, MN-64 was effective Wnt/β- catenin inhibitors at 1 μM, and inhibited STF luciferase activity at 200 nM [1].
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| Catalog Number | I005519 |
| CAS Number | 92831-11-3 |
| Synonyms | MN-64; MN 64; MN64. |
| Molecular Formula | C₁₈H₁₆O₂ |
| Purity | ≥95% |
| Target | Tankyrase 1 |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage | -20°C |
| IC50 | 6 nM |
| InChI | InChI=1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3 |
| InChIKey | PYTOHIUBXSJKQH-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2 |
| Reference | [1]. Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. doi: 10.1021/jm401463y. Epub 2013 Oct 11. PubMed PMID: 24116873.<br /> |
