For research use only. Not for therapeutic Use.
MNBA, also known as 4-methyl-3-nitro-benzoic acid, is a potential cell migration inhibitor, with potential anticancer activity. T reatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug .
| Catalog Number | I008121 |
| Synonyms | MNBA; 4methyl3nitrobenzoic acid;4-methyl-3-nitro-benzoic acid |
| Molecular Formula | C8H7NO4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | O=C(O)C1=CC=C(C)C([N+]([O-])=O)=C1 |
| Reference | </br>1: Chen P, Zhang X, Guo H, Ma N, Li M, Liu Z, Zhang N, Hao X. Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration. Mol Med Report. 2011 Sep-Oct;4(5):947-53. doi: 10.3892/mmr.2011.527. Epub 2011 Jul 1. PubMed PMID: 21725598.</br>2: Guo H, Li M, Chen P, Blake DJ, Kong X, Hao X, Niu R, Zhang N. 4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice. Cancer Lett. 2011 Jun 1;305(1):69-75. doi: 10.1016/j.canlet.2011.02.028. Epub 2011 Mar 22. Erratum in: Cancer Lett. 2012 Nov 28;324(2):232. PubMed PMID: 21429660. |
