For research use only. Not for therapeutic Use.
MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].
| Catalog Number | I008124 |
| CAS Number | 946619-21-2 |
| Synonyms | 4-(8-bromo-2-oxo-1,3-dihydro-1,5-benzodiazepin-4-yl)pyridine-2-carbonitrile |
| Molecular Formula | C15H9BrN4O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21) |
| InChIKey | KMKZCMKOSAKVGY-UHFFFAOYSA-N |
| SMILES | C1C(=NC2=C(C=C(C=C2)Br)NC1=O)C3=CC(=NC=C3)C#N |
| Reference | [1]. Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-264. |
