For research use only. Not for therapeutic Use.
MNK8（Cat No.:I043513）is a selective small-molecule inhibitor targeting MAPK-interacting kinases 1 and 2 (MNK1/2), which are downstream effectors of the MAPK signaling pathway. These kinases regulate the phosphorylation of eIF4E, a key factor in mRNA translation linked to cancer progression and inflammation. By inhibiting MNK1/2, MNK8 disrupts oncogenic protein synthesis, making it a promising therapeutic candidate for cancer and inflammatory diseases. MNK8 has shown potential in preclinical models for reducing tumor growth and modulating immune responses, and it serves as a valuable tool for studying translational control in disease biology.
| CAS Number | 2055078-49-2 |
| Synonyms | 3-methyl-6-naphthalen-1-yl-1H-pyrimidine-2,4-dione |
| Molecular Formula | C15H12N2O2 |
| Purity | ≥95% |
| IUPAC Name | 3-methyl-6-naphthalen-1-yl-1H-pyrimidine-2,4-dione |
| InChI | InChI=1S/C15H12N2O2/c1-17-14(18)9-13(16-15(17)19)12-8-4-6-10-5-2-3-7-11(10)12/h2-9H,1H3,(H,16,19) |
| InChIKey | SJRMGNRXVMMJSY-UHFFFAOYSA-N |
| SMILES | CN1C(=O)C=C(NC1=O)C2=CC=CC3=CC=CC=C32 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
