For research use only. Not for therapeutic Use.
MnTBAP chloride (CAT: I014981) serves as a potent superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. This manganic porphyrin complex possesses robust anti-oxidative properties, making it effective in counteracting oxidative stress-related damage. MnTBAP chloride exhibits anti-inflammatory effects by upregulating BMPR-II and inhibiting the NFκB signaling pathway. With its potential to modulate these pathways, MnTBAP chloride shows promise in the research of chronic kidney diseases (CKDs), particularly in addressing the fibrotic response.
| Catalog Number | I014981 |
| CAS Number | 55266-18-7 |
| Molecular Formula | C₄₈H₂₈ClMnN₄O₈ |
| Purity | ≥95% |
| Target | NF-κB |
| Reference | [1]. Jing Yu, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice With 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930.<br>[2]. Qian Zhou, et al. MnTBAP Increases BMPR-II Expression in Endothelial Cells and Attenuates Vascular Inflammation. Vascul Pharmacol. 2016 Sep;84:67-73. |
