MnTE-2-PyP chloride

• CAT Number: I023570
• CAS Number: 219818-60-7
• Molecular Formula: C48H44Cl5MnN8
• Molecular Weight: 965.12
• Purity: ≥95%

MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer[1].
MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation[1].
MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1].
MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment[1].
MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1].
MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1].
MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].

Reference

[1]. Arpita Chatterjee, et al. MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses. Redox Biol. 2020 Jul;34:101542.
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