Moclobemide is a reversible inhibitor of monoamine oxidase (RIMA) drug primarily used to treat depression and social anxiety. It is not approved for use in the United States, but is approved in other Western countries such as the UK and Australia. Due to the lack of anticholinergic, cardiovascular, cognitive and psychomotor impairments, moclobemide is advantageous in the elderly as well as those with cardiovascular disease. (https://en.wikipedia.org/wiki/Moclobemide)
| Catalog Number | A000232 |
| CAS Number | 71320-77-9 |
| Synonyms | NA |
| Molecular Formula | C₁₃H₁₇ClN₂O₂ |
| Purity | ≥95% |
| Target | MAO |
| Solubility | >9.9mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17) |
| InChIKey | YHXISWVBGDMDLQ-UHFFFAOYSA-N |
| SMILES | C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl |
| Reference | </br> 1: Bonnet U. Moclobemide: therapeutic use and clinical studies. CNS Drug Rev. 2003 Spring;9(1):97-140. Review. PubMed PMID: 12595913.</br>2: Bonnet U. Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties. CNS Drug Rev. 2002 Fall;8(3):283-308. Review. PubMed PMID: 12353059.</br>3: Gumà M, Clemente F, Segura A, Costa J. [The serotoninergic syndrome: moclobemide and citalopram]. Med Clin (Barc). 1999 Nov 20;113(17):677-8. Review. Spanish. PubMed PMID: 10618787.</br>4: Amrein R, Martin JR, Cameron AM. Moclobemide in patients with dementia and depression. Adv Neurol. 1999;80:509-19. Review. PubMed PMID: 10410765.</br>5: Versiani M. Pharmacotherapy of dysthymic and chronic depressive disorders: overview with focus on moclobemide. J Affect Disord. 1998 Dec;51(3):323-32. Review. PubMed PMID: 10333986.</br>6: Goldberg RJ. Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide. Drugs Aging. 1997 Aug;11(2):119-31. Review. PubMed PMID: 9259175.</br>7: Fulton B, Benfield P. Moclobemide. An update of its pharmacological properties and therapeutic use. Drugs. 1996 Sep;52(3):450-74. Review. Erratum in: Drugs 1996 Dec;52(6):869. PubMed PMID: 8875133.</br>8: Nutt D, Montgomery SA. Moclobemide in the treatment of social phobia. Int Clin Psychopharmacol. 1996 Jun;11 Suppl 3:77-82. Review. PubMed PMID: 8923114.</br>9: Angst J, Amrein R, Stabl M. Moclobemide: a paradigm of research in clinical psychopharmacology. Int Clin Psychopharmacol. 1996 Jun;11 Suppl 3:3-7. Review. PubMed PMID: 8923103.</br>10: Mayersohn M, Guentert TW. Clinical pharmacokinetics of the monoamine oxidase-A inhibitor moclobemide. Clin Pharmacokinet. 1995 Nov;29(5):292-332. Review. PubMed PMID: 8582117.</br>11: Hilton S, Jaber B, Ruch R. Moclobemide safety: monitoring a newly developed product in the 1990s. J Clin Psychopharmacol. 1995 Aug;15(4 Suppl 2):76S-83S. Review. PubMed PMID: 7593735.</br>12: Norman TR, Burrows GD. A risk-benefit assessment of moclobemide in the treatment of depressive disorders. Drug Saf. 1995 Jan;12(1):46-54. Review. PubMed PMID: 7741983.</br>13: Freeman H. Moclobemide. Lancet. 1993 Dec 18-25;342(8886-8887):1528-32. Review. PubMed PMID: 7902906.</br>14: Nair NP, Ahmed SK, Kin NM. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide. J Psychiatry Neurosci. 1993 Nov;18(5):214-25. Review. PubMed PMID: 7905288; PubMed Central PMCID: PMC1188542.</br>15: Tiller JW. Clinical overview on moclobemide. Prog Neuropsychopharmacol Biol Psychiatry. 1993 Sep;17(5):703-12. Review. PubMed PMID: 8255982.</br>16: Dingemanse J. An update of recent moclobemide interaction data. Int Clin Psychopharmacol. 1993 Jan;7(3-4):167-80. Review. PubMed PMID: 8468439.</br>17: Woggon B. The role of moclobemide in endogenous depression: a survey of recent data. Int Clin Psychopharmacol. 1993 Jan;7(3-4):137-9. Review. PubMed PMID: 8468434.</br>18: Silverstone T. Moclobemide–placebo-controlled trials. Int Clin Psychopharmacol. 1993 Jan;7(3-4):133-6. Review. PubMed PMID: 8468433.</br>19: Amrein R, Hetzel W, Stabl M, Schmid-Burgk W. RIMA–a new concept in the treatment of depression with moclobemide. Int Clin Psychopharmacol. 1993 Jan;7(3-4):123-32. Review. PubMed PMID: 8468432.</br>20: Haefely W, Burkard WP, Cesura A, Colzi A, Kettler R, Lorez HP, Martin JR, Moreau JL, Richards JG, Schaffner R, et al. Pharmacology of moclobemide. Clin Neuropharmacol. 1993;16 Suppl 2:S8-18. Review. PubMed PMID: 8313402.</br></br> |
