Moexipril hydrochloride

• CAT Number: I004987
• CAS Number: 82586-52-5
• Molecular Formula: C27H34N2O7 • HCl
• Molecular Weight: 535.00
• Purity: ≥95%
• Synonyms: CI-925;RS 10085-197;SPM 925
• Target: ACE
• Solubility: DMSO 20 mg/mL; Water <1 mg/mL
• Storage: 2-8°C
• IUPAC Name: (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1
• InChIKey: JXRAXHBVZQZSIC-JKVLGAQCSA-N
• SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC(=C(C=C3C[C@H]2C(=O)O)OC)OC.Cl

Moexipril HCl（Cat No.:I004987）is a potent orally active angiotensin-converting enzyme (ACE) inhibitor that does not contain a sulfhydryl group. It is primarily used in the treatment of hypertension (high blood pressure) and congestive heart failure. By inhibiting ACE, Moexipril HCl blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in vasodilation and decreased blood pressure. Moexipril HCl is typically administered orally and is well-tolerated, making it an effective choice for managing hypertension and heart failure in patients.

Reference

[1]. Chrysant, S.G. and G.S. Chrysant, Pharmacological and clinical profile of moexipril: a concise review. J Clin Pharmacol, 2004. 44(8): p. 827-36.
[2]. Edling, O., et al., Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J Pharmacol Exp Ther, 1995. 275(2): p. 854-63.
[3]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.