Mofegiline hydrochloride

• CAT Number: I000763
• CAS Number: 120635-25-8
• Molecular Formula: C11H14ClF2N
• Molecular Weight: 233.69
• Purity: ≥95%
• Synonyms: Mofegiline HCl；
• Target: Monoamine Oxidase
• Solubility: H2O: ≥ 39 mg/mL
• Storage: Store at -20°C
• IC50: 3.6 nM
• IUPAC Name: (2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine;hydrochloride
• InChI: InChI=1S/C11H13F2N.ClH/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9;/h3-7H,1-2,8,14H2;1H/b10-7+
• InChIKey: QUCNNQHLIHGBIA-HCUGZAAXSA-N
• SMILES: C1=CC(=CC=C1CCC(=CF)CN)F.Cl

Mofegiline Hcl (Cat.No:I000763), also known as MDL-72974, or MDL-72974A (HCl salt),  is a potent and selective enzyme-activated irreversible inhibitor of MAO-B; shows marked selectivity for the B form (IC50 = 680 and 3.6 nM for MAO-A and MAO-B, respectively. It was under investigation for the treatment of Parkinson's disease and Alzheimer's disease, but was never marketed.

Reference

[1]. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson/'s disease. J Neural Transm Park Dis Dement Sect. 1989;1(4):243-54.
[2]. Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1992 Jan 22;43(2):307-12.
[3]. Dow J, et al. Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug Metab Dispos. 1994 Sep-Oct;22(5):738-49.