For research use only. Not for therapeutic Use.
Moguisteine (Cat No.:I000716) is a peripheral non-narcotic antitussive drug that is used to treat coughing. It is classified as a novel antitussive due to its unique mechanism of action. Moguisteine acts on the peripheral nervous system, specifically targeting the sensory nerve endings in the respiratory tract to suppress cough reflexes. Unlike narcotic antitussives, it does not possess addictive properties or cause sedation. Moguisteine offers a non-narcotic alternative for the symptomatic relief of cough, providing an effective treatment option with reduced potential for abuse and side effects.
| Catalog Number | I000716 |
| CAS Number | 119637-67-1 |
| Synonyms | BBR-2173; |
| Molecular Formula | C16H21NO5S |
| Purity | ≥95% |
| Target | cholinergic receptor antagonist |
| Solubility | DMSO 70 mg/mL; Water <1 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxopropanoate |
| InChI | InChI=1S/C16H21NO5S/c1-3-21-16(19)10-14(18)17-8-9-23-15(17)11-22-13-7-5-4-6-12(13)20-2/h4-7,15H,3,8-11H2,1-2H3 |
| InChIKey | WSYVIAQNTFPTBI-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CC(=O)N1CCSC1COC2=CC=CC=C2OC |
| Reference | </br>1:Determination of the active metabolite of moguisteine in human plasma and urine by LC-ESI-MS method and its application in pharmacokinetic study. Teng Y, Song H, Bu F, Wei C, Zhao W, Zhang R, Yuan G, Liu X, Wang B, Guo R.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:31-5. doi: 10.1016/j.jchromb.2012.04.033. Epub 2012 May 4. PMID: 22626894 </br>2:Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs. Morita K, Onodera K, Kamei J.Jpn J Pharmacol. 2002 Jun;89(2):171-5. PMID: 12120760 Free Article</br>3:Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine. Morita K, Kamei J.Eur J Pharmacol. 2000 Apr 28;395(2):161-4. PMID: 10794823 </br>4:Effects of moguisteine on the cough reflex induced by afferent electrical stimulation of the superior laryngeal nerve in guinea pigs. Ishii R, Furuta M, Hashimoto M, Naruse T, Gallico L, Ceserani R.Eur J Pharmacol. 1998 Dec 4;362(2-3):207-12. PMID: 9874172 </br>5:Antitussive effect of moguisteine on allergic coughs in the guinea pig. Kamei J, Morita K, Kashiwazaki T, Ohsawa M.Eur J Pharmacol. 1998 Apr 24;347(2-3):253-5. PMID: 9653890 </br>6:Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog. Sant/’Ambrogio G, Sant/’Ambrogio FB.Eur Respir J. 1998 Feb;11(2):339-44. PMID: 9551735 Free Article</br>7:Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig. Morikawa T, Gallico L, Widdicombe J.Pharmacol Res. 1997 Feb;35(2):113-8. PMID: 9175579 </br>8:Comparative toxicology of two enantiomers of the peripherally acting non-narcotic antitussive drug moguisteine. Cavalletti E, Montaguti P, Sala F, Ceserani R.Arzneimittelforschung. 1996 Dec;46(12):1114-9. PMID: 9006784 </br>9:Antitussive effect of moguisteine on the enhanced coughing associated with enalapril in guinea-pig. Kamei J, Morita K.Eur J Pharmacol. 1996 Sep 26;312(2):235-9. PMID: 8894601 </br>10:Effects of moguisteine, a peripheral nonnarcotic antitussive agent, on airway inflammation in guinea-pigs in vivo. Gallico L, Oggioni N, Dalla Rosa C, Ceserani R, Tognella S.Eur Respir J. 1996 Mar;9(3):478-85. PMID: 8730007 Free Article |
