Monastrol

• CAT Number: R001547
• CAS Number: 329689-23-8
• Molecular Formula: C14H16N2O3S
• Molecular Weight: 292.35
• Purity: ≥95%
• Synonyms: 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Target: Kinesin
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
• InChI: InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
• InChIKey: LOBCDGHHHHGHFA-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C

Monastrol（Cat No.:R001547）, is a synthetic small molecule that acts as a selective inhibitor of the kinesin Eg5. Eg5 is a motor protein involved in cell division, specifically in the formation and function of the mitotic spindle during mitosis. By inhibiting Eg5, Monastrol disrupts the proper assembly and function of the mitotic spindle, leading to mitotic arrest and cell cycle disruption. Due to its specific action on Eg5, Monastrol has been widely used as a valuable tool in cell biology and as a potential candidate for anti-cancer drug development.