For research use only. Not for therapeutic Use.
MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions[1].
| Catalog Number | I011297 |
| CAS Number | 1572936-83-4 |
| Synonyms | 2-[(4-methoxynaphthalen-2-yl)amino]-5-nitrobenzoic acid |
| Molecular Formula | C18H14N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H14N2O5/c1-25-17-9-12(8-11-4-2-3-5-14(11)17)19-16-7-6-13(20(23)24)10-15(16)18(21)22/h2-10,19H,1H3,(H,21,22) |
| InChIKey | JIVRLHBAUUZTNC-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC2=CC=CC=C21)NC3=C(C=C(C=C3)[N+](=O)[O-])C(=O)O |
| Reference | [1]. Oh SJ, et al. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol Pharmacol. 2013 Nov;84(5):726-35. |
