Mono-POC Tenofovir 6-Isopropyl Carbamate(Mixture of Diastereomers)

For research use only. Not for therapeutic Use.

  • CAT Number: R046834
  • CAS Number: 1244022-56-7
  • Molecular Formula: C18H28N5O9P
  • Molecular Weight: 489.422
  • Purity: ≥95%
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Mono-POC tenofovir 6-isopropyl carbamate (mixture of diastereomers) is a derivative of tenofovir, a nucleotide analog reverse transcriptase inhibitor used in the treatment of HIV/AIDS and hepatitis B. This compound is a mixture of diastereomers, each with unique properties. Research focuses on its synthesis, pharmacological activity, and potential as a prodrug to improve the bioavailability and pharmacokinetic profile of tenofovir. Studies aim to optimize its formulation for enhanced efficacy and reduced toxicity in antiviral therapy.


CAS Number 1244022-56-7
Synonyms

(8R)-9-(6-Isopropylaminocarbamate-9H-purin-9-yl)-5-hydroxy-8-methyl-2,4,7-trioxa-5-phosphanonanoic Acid 1-Methylethyl Ester 5-Oxide;

Molecular Formula C18H28N5O9P
Purity ≥95%
Storage -20°C
IUPAC Name [(2R)-1-[6-(propan-2-yloxycarbonylamino)purin-9-yl]propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid
InChI InChI=1S/C18H28N5O9P/c1-11(2)31-17(24)22-15-14-16(20-7-19-15)23(8-21-14)6-13(5)29-10-33(26,27)30-9-28-18(25)32-12(3)4/h7-8,11-13H,6,9-10H2,1-5H3,(H,26,27)(H,19,20,22,24)/t13-/m1/s1
InChIKey CEFDJALYGKEXAQ-CYBMUJFWSA-N
SMILES CC(C)OC(=O)NC1=NC=NC2=C1N=CN2CC(C)OCP(=O)(O)OCOC(=O)OC(C)C

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