Monomethyl auristatin E intermediate-11

• CAT Number: I040445
• CAS Number: 870640-62-3
• Molecular Formula: C14H23NO
• Molecular Weight: 221.34
• Purity: ≥95%
• Synonyms: (2S,3S)-2-[benzyl(methyl)amino]-3-methylpentan-1-ol
• InChI: InChI=1S/C14H23NO/c1-4-12(2)14(11-16)15(3)10-13-8-6-5-7-9-13/h5-9,12,14,16H,4,10-11H2,1-3H3/t12-,14+/m0/s1
• InChIKey: JPXSDNBZAYWWCL-GXTWGEPZSA-N
• SMILES: CCC(C)C(CO)N(C)CC1=CC=CC=C1

Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Reference

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
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