Monomethyl auristatin E intermediate-14

• CAT Number: I040444
• CAS Number: 1932791-56-4
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.30
• Purity: ≥95%
• Synonyms: (2R,3S)-2-(benzylamino)-3-methylpentanoic acid
• InChI: InChI=1S/C13H19NO2/c1-3-10(2)12(13(15)16)14-9-11-7-5-4-6-8-11/h4-8,10,12,14H,3,9H2,1-2H3,(H,15,16)/t10-,12+/m0/s1
• InChIKey: GPAVORZIWQTJJQ-CMPLNLGQSA-N
• SMILES: CCC(C)C(C(=O)O)NCC1=CC=CC=C1

Monomethyl auristatin E intermediate-14 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Reference

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
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