Monomethyl auristatin E intermediate-3

• CAT Number: I040261
• Molecular Formula: C14H19NO4
• Molecular Weight: 265.30
• Purity: ≥95%
• Synonyms: 3-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
• InChI: InChI=1S/C14H19NO4/c1-3-10(2)12(13(16)17)15-14(18)19-9-11-7-5-4-6-8-11/h4-8,10,12H,3,9H2,1-2H3,(H,15,18)(H,16,17)
• InChIKey: JSHXJPFZKBRLFU-UHFFFAOYSA-N
• SMILES: CCC(C)C(C(=O)O)NC(=O)OCC1=CC=CC=C1

Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Reference

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
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